Here are some projects I worked on in college, competitions, internships, and elsewhere. Please feel free to reach out to me if you would like to learn more about them.
Development of Railways in the Last Decade With a Special Focus on West Bengal
As a Policy in Action fellow for Young Leaders for Active Citizenship (YLAC), I worked on a project for the MP Derek O’Brien with Aishwarya Chandrasekhar, Chakshu Bhandari, Ipshita Karmakar, and Tanya Jain, where we analysed the development of the Indian Railways over the past decade, with an emphasis on how these changes have affected West Bengal. The trends in budget allocations and utilization over the past decade have been discussed. West Bengal’s developments were also compared with that of Bihar and Maharashtra. From our observations, we recommended a set of policies to be implemented and courses of action to be taken to overcome factors that inhibit railway infrastructural development in West Bengal, with reference to related economic and political challenges.
Redesigned Sanitary Napkin
I conceptualized a redesigned sanitary napkin with three layers – antimicrobial, absorbent, and waterproof, inspired by how nature cleans and maintains its surroundings. The antimicrobial layer will prevent bacteria from colonizing on the surface, the absorbent layer will absorb and retain large amounts of fluid, making it longer lasting, and the waterproof layer will prevent leakages but still ensure that it is breathable and comfortable. These salient features are achieved by nature of the structure alone, without the use of any harsh chemicals. This project is connected to the UN Sustainable Development Goal 5 – Gender Equality, and was conceptualized in the course Introduction to Biomimicry under Prof. Shiva Subramaniam, Prof. Satyanarayanan Seshadri, and Prof. Sivakumar M S.
I conceptualized a pop-up textile upcycling workshop, as a part of the ‘Hacking the Fast Fashion Crisis’ Mini Hackathon, conducted by Earth Hacks and Smith College, Massachusetts, along with Shalini Gupta, Alice Zhang, and Mandy Li.
Molecular dynamics simulation analysis of the epidermal growth factor receptor protein architecture
In this project, the architecture of the epidermal growth factor receptor (EGFR) kinase domain was studied in detail. Molecular dynamics simulations were done using Gromacs, and a 1 nsec MD run was performed. The force field used was GROMOS96 43a1, and the water model used was TIP3P. Analyses were performed using inbuilt Gromacs tools to find the values of root mean square fluctuation, root mean square deviation, radius of gyration, and solvent accessible surface area. The results and conclusions were presented as a part of the course Computer Simulations of Biomolecular Systems under Prof. Hamsa Priya.
I identified new possible inhibitors of Human Furin Endoprotease (a target of SARS-Cov-2) by developing a pharmacophore model using known ligands reported for inhibiting the target (chosen from literature). The docking score of the shortlisted molecules was compared with that of reported inhibitors, and their PK and the drug likeness properties/ADME were observed, and conclusions were presented, as a part of the course Molecular Modeling and Drug Design under Prof. Mukesh Doble, along with Mounika Kambham.
Estimation of Model Parameters for Gene Regulatory Networks
I used MATLAB to estimate the model parameters required to characterize the kinetics of gene regulatory networks by optimally choosing data from available experiments in order to get the most accurate results. Three different gene regulatory networks were defined, each having a different number of parameters to be estimated. Using the maximum likelihood parameter estimation method, latin hypercube sampling, and a select amount of the available experimental data, biologically meaningful parameters were estimated for the three models, as a part of the course Computational Systems Biology under Prof. Karthik Raman, along with Guru Pramoth.
Optimization of algae cultivation in sugar effluents for biofuel production
Along with Pooja from IIT Madras, I worked on optimizing the algae cultivation in sugar effluents for biofuel production, to implement in the sugar manufacturing industry. Algal Biofuel is an alternative fuel produced from algae. Algae can be cultivated using certain effluents from the sugar mill industry as a growth medium. This in turn considerably purifies the effluent before it is released into the environment. Scenedesmus obliquus, an alga known for its high lipid content, was chosen to be the biomass for biofuel production. The amount of carbon dioxide to be supplied to it in order to maximize its growth rate, was studied. The subsequent growth rate of the algae was analysed. This was part of an internship with the research center of the Murugappa Group.
Modelling the flow of money according to the theory of Trickle-Down Economics
I modelled the flow of money through the economy according to the theory of Trickle-Down economics, using MATLAB, in order to determine its impact on society at large, as a course project for Transport Phenomena in Biological Systems under Prof. G K Suraishkumar.